Formula C1

Catalyst

Catalyst

Catalyst - Formula C1. Thiamine HCl 500mg, 30 servings.

Do you ever find yourself midway through the day and wondering why you're struggling to find the energy to get through it? Sure another coffee or energy drink could help, but don't you think your biology is more than equipped to get through 24 hours? Maybe it's time to quit the bandaid fixes and address something more fundamental, your energy metabolism.

Catalyst offers 500mg of Thiamine HCl. Thiamine, otherwise known as the energy gatekeeper, is a critical nutrient responsible for converting the food we eat into the energy we need. Thiamine plays a pivotal role in efficient energy metabolism; it doesn't create the illusion of energy, but instead supports the metabolic systems responsible for making it.

Catalyst's goal isn't to make you feel wired or locked in, its goal is to support your biology and the systems responsible for how much energy your body can make and use. That means supporting the foundation behind your physical energy, mental output, and your ability to keep going when the day still has plenty left in it.

$35.00
$35.00
Sale Sold out
Shipping calculated at checkout.

Description

Catalyst - Formula C1. Thiamine HCl 500mg, 30 servings.

Do you ever find yourself midway through the day and wondering why you're struggling to find the energy to get through it? Sure another coffee or energy drink could help, but don't you think your biology is more than equipped to get through 24 hours? Maybe it's time to quit the bandaid fixes and address something more fundamental, your energy metabolism.

Catalyst offers 500mg of Thiamine HCl. Thiamine, otherwise known as the energy gatekeeper, is a critical nutrient responsible for converting the food we eat into the energy we need. Thiamine plays a pivotal role in efficient energy metabolism; it doesn't create the illusion of energy, but instead supports the metabolic systems responsible for making it.

Catalyst's goal isn't to make you feel wired or locked in, its goal is to support your biology and the systems responsible for how much energy your body can make and use. That means supporting the foundation behind your physical energy, mental output, and your ability to keep going when the day still has plenty left in it.

Benefits
  • Cellular energy production
  • Carbohydrate metabolism
  • Mitochondrial support
  • Nervous system function
  • Cellular redox support
  • Cardiac Energy metabolism
  • Mental energy and reaction speed
  • Energy metabolism during physical demand

Supp Facts
Catalyst Supplement Facts

How to Take

Take 1 capsule with a meal containing carbohydrates, assess response, and redose later if desired.

References
  1. Kerns JC, Gutierrez JL. Thiamin. Advances in Nutrition. 2017. Excellent foundational review covering PDH, alpha-KGDH, BCKDH and transketolase. Source
  2. NIH Office of Dietary Supplements. Authoritative support that vitamin B1 helps convert food into usable energy. Source
  3. Palmieri L, et al. Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD+, and related diseases: A review. Discusses ThPP entry into mitochondria and use by PDH, OGDH, BCKDH and other enzymes. Source
  4. Szabo E, et al. Mitochondrial Alpha-Keto Acid Dehydrogenase Complexes: Recent Developments on Structure and Function in Health and Disease. Reinforces the central roles of PDH, alpha-KGDH and BCKDH in energy metabolism. Source
  5. Alaei-Shahmiri F, et al. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. Eur J Nutr. 2013. PMID 23715873. Thiamine HCl, 300 mg/day. Source
  6. Hassan R, et al. Effect of thiamine on glucose utilization in hepatic cirrhosis. Thiamine HCl, 50 mg/day; useful supporting evidence but old and disease-specific. Source
  7. Maguire D, et al. The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review. Systematic review discussing thiamine, transketolase, PDH, alpha-KGDH and glucose handling. Good substantiation material, not a customer-facing disease claim. Source
  8. Abdou E, Hazell AS. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Neurochem Res. 2015. PMID 25297573. Source
  9. Benton D, Griffiths R, Haller J. Thiamine supplementation mood and cognitive functioning. Psychopharmacology. 1997. PMID 9122365. Source
  10. Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine and cobalamin. CNS Neurosci Ther. 2020. Source
  11. Aleshin VA, Mkrtchyan GV, Bunik VI. Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance. Discusses glucose oxidation, neuronal function, ion-channel effects and cholinergic neurotransmission. Source
  12. Abdou E, Hazell AS. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Strong review connecting inadequate thiamine-dependent metabolism to impaired brain mitochondrial energy metabolism. Source
  13. Schenk G, Duggleby RG, Nixon PF. Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Int J Biochem Cell Biol. PMID 9924800. Source
  14. Singleton CK, Martin PR. Molecular mechanisms of thiamine utilization. Review detailing thiamine-dependent metabolism, transketolase, reducing equivalents and pentose production. Source
  15. TeSlaa T, Ralser M, Fan J, Rabinowitz JD. The pentose phosphate pathway in health and disease. Nature Metabolism. 2023. Describes the PPP's production of NADPH and its role in redox homeostasis and biosynthesis. Source
  16. Kerns & Gutierrez. Thiamin. Also explains that PPP-derived reducing equivalents participate in maintaining glutathione and supporting biosynthetic reactions. Source
  17. Li J, et al. Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. J Biol Chem. 2004. PMID 15166214. Demonstrates the ThDP dependence of the human BCKDH complex. Source
  18. Kerns & Gutierrez. Thiamin. Nutritional overview describing thiamine's role in branched-chain amino acid catabolism. Source
  19. Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000. Exercise/nutrition review discussing thiamine-dependent metabolism and the increased metabolic demands associated with physical activity. Source
  20. DiNicolantonio JJ, Liu J, O'Keefe JH. Thiamine and Cardiovascular Disease: A Literature Review. Prog Cardiovasc Dis. 2018. PMID 29360523. Source
  21. Ahmed M, et al. Thiamin deficiency and heart failure: the current knowledge and gaps in literature. Heart Fail Rev. 2015. PMID 24811895. Explicitly discusses thiamine-dependent reactions fueling myocardial contraction. Source
  22. Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-induced fatigue. Metab Brain Dis. 1996. PMID 8815395. Source
  23. The Effect of Thiamine Depletion and Restoration of Muscular Efficiency and Endurance. Journal of Nutrition. 1944;28(4):241–254. Thiamine HCl improved endurance under experimentally low-vitamin conditions. Source
  24. Smithline HA, Donnino M, Greenblatt DJ. Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. BMC Clin Pharmacol. 2012. PMID 22305197. Source

Lab Reports

Third-party lab reports coming soon.

Reviews — coming soon.

Complete the Foundation — Add Conduit

View Conduit